Dhodapkar 1..9
نویسندگان
چکیده
, 232ra51 (2014); 6 Sci Transl Med et al. Madhav V. Dhodapkar NY-ESO-1 to the Dendritic Cell Receptor DEC-205 Induction of Antigen-Specific Immunity with a Vaccine Targeting Editor's Summary additional avenue to boost the immune response to cancer. these data can be reproduced in larger trials, this study suggests that targeting antigen to dendritic cells could be an either stable disease or disease regression, particularly those who had received immune checkpoint inhibitors. If humoral and cellular immunity in these patients, with no dose-limiting toxicities. What's more, a subset of patients had added Toll-like receptor ligands as adjuvants in a dose-escalating study. They found that treatment induced both fused with the tumor antigen NY-ESO-1 in a cohort of patients with tumors refractory to other therapies. They also The authors tested a vaccine that consisted of a human antibody targeted to the dendritic cell receptor DEC-205 attempt to overcome this inhibition by targeting a tumor antigen directly to dendritic cells. et al. activation. Dhodapkar context for the T cell to react. However, tumor alters the nearby microenvironment in such a way as to block immune Dendritic cells are the matchmakers of the immune system: They introduce T cells to antigen, providing the right Start Spreading the News
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